산학융합 아이콘 플랫폼
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연구인력 정보

아이콘

하형호

HA HYUNG-HO

유기약화학 및 의약화학

의약화학

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전화번호 061-750-3754

이메일 hhha@sunchon.ac.kr

연구인력 상세정보

순번 연구분야 연구핵심명
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연구과제

순번 과제명 기관명 기간
1 한국화합물은행 위탁합성 공모과제 한국화학연구원 20141001~20141231
2 새로운 진해거담 치료제의 임상개발 산업통상자원부. 20151201~20160930
3 Nanthen library를 이용한 세포 선택적 형광탐침자의 개발 기초과학연구원 20190101~20191231
4 미세조류유래 독창적 신규 약물성 라이브러리 구축 및 응용연구 재)순천천연물의약소재개발연구센터 20120901~20121231
5 암 전이 억제제 개발을 위한[18F]-표지 PET 영상제의 합성 및 평가 한국연구재단 20150601~20160531
6 (사업)고흥웰빙 불로초(석류, 유자, 참다래)기능성 소재개발 및 사업화지원 산업통상자원부 20180401~20181231
7 KITENIN 타겟 새로운 암전이 억제제 후보물질 합성 및 암세포 진단 영상제 개발연구 한국연구재단 20170901~20180831
8 Nanthen library를 이용한 세포 선택적 형광탐침자의 개발 기초과학연구원 20180101~20181231
9 Design and synthesis of scaffold-based small Molecule Library 일반기업체 20220301~20230228
10 신규 표적단백질 분해체의 디자인 및 유도체 합성 일반기업체 20220701~20230630
11 Scaffold Hopping을 통한 CR-E1 활성 Th17 면역반응을 제어하는 First0in-class의 자가면역질환 치료제 선도물질 도출 연구 중소벤처기업부 20230501~20231231
12 한국화합물은행 위탁합성 공모과제 한국화학연구원 20130801~20131231
13 미래 기능성 소재를 위한 피리미딘을 함유한 천연물과 유기 발광재료 합성 한국연구재단 20120920~20130919
14 신규 표적단백질 분해체의 디자인 및 유도체 합성 일반기업체 20210701~20220630
15 Novel CR-E1 억제제 디자인 및 합성을 통한 후보물질 도출 연구 일반기업체 20210101~20211231
16 탈인산화효소 표적단백질 분해제의 신규유도체 합성 일반기업체 20250101~20251031
17 KITENIN 타겟 새로운 암전이 억제제 후보물질 합성 및 암세포 진단 영상제 개발연구 한국연구재단 20160901~20170831
18 의약 저해활성 핵심중간체인 Cyclopentylamine의 연구분석 한국화학연구원 20160801~20161030
19 피라졸로피리딘 유도체의 합성경로 구출 및 유도체 합성 한국화학연구원 20170901~20171130
20 항암제 개발을 위한 대조물질 합성 및 대량 합성법 개발 한국화학연구원 20180901~20181130
21 당뇨 조기 진단을 위한 기계학습 및 딥러닝 모델 최적화 연구 순천대학교 20240601~20250228
22 미세조류유래 독창적 신규 약물성 라이브러리 구축 및 응용연구 (재)순천천연물의약소재개발연구센터 20130101~20131231
23 (사업)고흥웰빙 불로초(석류,유자,참다래)기능성 소재개발 및 사업화지원 산업통상자원부 20200101~20201231
24 KITENIN 타겟 새로운 암전이 억제제 후보물질 합성 및 암세포 진단 영상제 개발연구 한국연구재단 20150901~20160831
25 식물 추출물 복합소재를 이용한 호흡기 건강 개선 제품 개발 산업통상자원부. 20161001~20170930
26 항바이러스 기전의 새로운 호흡기질환 천연물 복합 치료제 개발 (재)순천천연물의약소재개발연구센터 20130101~20131231
27 핵심중간체 4-amino-3-methyl-5-(methylthio)benzonitrile의 합성 및 합성경로 구축연구 한국화학연구원 20170301~20170430
28 (사업)고흥웰빙 불로초(석류, 유자, 참다래)기능성 소재개발 및 사업화지원 한국산업기술진흥원 20190101~20191231

학술논문

순번 제목 기관명 기간
1 Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects ROYAL SOC CHEMISTRY 201102
2 The Binding of Fluorophores to Proteins Depends on the Cellular Environment WILEY-BLACKWELL 201103
3 Fluorescent labeling of membrane proteins on the surface of living cells by a self-catalytic glutathione S-transferase omega 1 tag ROYAL SOC CHEMISTRY 201104
4 Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach RSC 201104
5 Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling CISRO 201105
6 Embryonic and induced pluripotent stem cell staining and sorting with the live-cell fluorescence imaging probe CDy1 NATURE PUBLISHING GROUP 201106
7 Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues ROYAL SOC CHEMISTRY 201110
8 Solid phase synthesis of ultra-photostable cyanine NIR dye library ROYAL SOC CHEMISTRY 201108
9 Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe ROYAL SOC CHEMISTRY 201107
10 A Triazine Compound S06 Inhibits Proinvasive Crosstalk between Carcinoma Cells and Stromal Fibroblasts via Binding to Heat Shock Protein 90 CELL PRESS 201112
11 A fluorescent screening platform for the rapid evaluation of chemicals in cellular reprogramming Elsevier 201207
12 Combinatorial Solid-Phase Synthesis of 4,6-Diaryl and 4-Aryl, 6-Alkyl-1,3,5-triazines and Their Application to Efficient Biofuel Production AMER CHEMICAL SOC 201207
13 A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes AMER CHEMICAL SOC 201306
14 Visualization and Isolation of Langerhans Islets by a Fluorescent Probe PiY WILEY-V C H VERLAG GMBH 201308
15 Diversity Oriented Fluorescence Library Approach (DOFLA) for Live Cell Imaging Probe Development ACS 201312
16 Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking INFORMA HEALTHCARE 201406
17 A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation ROYAL SOC CHEMISTRY 201405
18 Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses ELSEVIER SCIENCE BV 201405
19 Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation Elsevier 201411
20 Diversity-Oriented Approach for Chemical Biology WILEY-V C H VERLAG GMBH 201504
21 Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient ROYAL SOC CHEMISTRY 201504
22 Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility PUBLIC LIBRARY SCIENCE 201509
23 Inhibitory Activity of Usnic Acid against Non-Small Cell Lung Cancer Cell Motility PLOS 201601
24 Development of background-free tame fluorescent probes for intracellular live cell imaging NATURE PUBLISHING GROUP 201606
25 ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes Nature 201703
26 Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin–p120-Catenin Complex MDPI 201712
27 Mitochondria are physiologically maintained at close to 50 degrees C PUBLIC LIBRARY SCIENCE 201801
28 Physciosporin Suppresses the Proliferation, Motility and Tumourigenesis of Colorectal Cancer Cells Elsevier 201809
29 Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells MDPI 201811
30 Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer Nature 201811
31 Antimicrobial Activity of Divaricatic Acid Isolated from the Lichen Evernia mesomorpha against Methicillin-Resistant Staphylococcus aureus MDPI 201811
32 Fabrication of Gd-La codoped TiO2 composite via a liquid phase plasma method and its application as visible-light photocatalysts Elsevier 201812
33 Differences in the molecular signatures of mucosal-associated invariant T cells and conventional T cells Nature 201905
34 A Near-Infrared Probe Tracks and Treats Lung Tumor Initiating Cells by Targeting HMOX2 ACS Publications 201908
35 Assessment of Degradation Behavior for Acetylsalicylic cid Using a Plasma in Liquid Process MDPI 201911
36 Degradation behaviors of naproxen by a hybrid TiO2 photocatalyst system with process components ELSEVIER 201910
37 Fabrication of Yb-doped TiO<inf>2</inf> using liquid phase plasma process and its photocatalytic degradation activity of naproxen Springer 202001
38 The photocatalytic destruction of cimetidine using microwave-assisted TiO2 photocatalysts hybrid system ELSEVIER 202006
39 Assessing the photocatalytic activity of europium doped TiO<INF>2</INF> using liquid phase plasma process on acetylsalicylic acid Elsevier B.V. 202006
40 Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression NLM (Medline) 202106
41 A heptamethine cyanine dye serves as a potential marker for myeloid-derived suppressor cells E-CENTURY PUBLISHING CORP 202106
42 Transcriptome analysis upon potassium usnate exposure reveals ATF3-induced apoptosis in human gastric and colon cancer cells Elsevier GmbH 202107
43 Physciosporin suppresses mitochondrial respiration, aerobic glycolysis, and tumorigenesis in breast cancer Elsevier GmbH 202107
44 A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex BioMed Central Ltd 202105
45 New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D Wiley 202108
46 Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library Royal Society of Chemistry 202108
47 Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility Nature Research 202212
48 Topical Delivery of Atraric Acid Derived from Stereocaulon japonicum with Enhanced Skin Permeation and Hair Regrowth Activity for Androgenic Alopecia MDPI 202302
49 KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer BioMed Central Ltd 202312
50 Usnic Acid Targets 14-3-3 Proteins and Suppresses Cancer Progression by Blocking Substrate Interaction American Chemical Society 202401
51 Metastasis-enhancing protein KITENIN confers temozolomide resistance on glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers JOHN WILEY & SONS LTD 202407
52 A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging ACS 202412
53 Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound ELSEVIER GMBH 202411
54 Development and synthesis of diffractaic acid analogs as potent inhibitors of colorectal cancer stem cell traits NATURE PORTFOLIO 202502
55 4-O-Demethylbarbatic acid has a novel therapeutic impact on the progression of EGFR-driven lung adenocarcinoma ELSEVIER GMBH 202509

학술서적

순번 제목 출판사 출판일
1 의약화학 도서출판 신일북스 2011-08-30
2 의약품합성학 의약품합성학편찬위원회 동명사 2012-02-25
3 실험의약품합성학 실험의약품편찬위원회 청문각 2013-02-20
4 제약산업학 제약산업학교재편찬위원회(명지문화사) 2013-02-20
5 Solid-Phase Organic Synthesis Wiley 2012-03-02
6 의약화학 신일서적 2019-03-04
7 의약화학 신일서적 2023-03-02
8 마스터톤의 일반화학 센게이지러닝코리아 2019-03-01
9 실버버그의 일반화학 사이플러스 2019-03-01
10 줌달의 일반화학 센게이지러닝코리아 2019-03-04
11 클라인의 유기화학 사이플러스 2020-03-01
12 레이먼드 창의 일반화학 14판 사이플러스 2023-03-01
13 레이먼드 창의 기본 일반화학 14판 사이플러스 2023-03-01
14 실버버그의 일반화학 9판 사이플러스 2023-03-01

지식재산권

순번 제목 분류명 등록일
1 Use of Pyrazole-pyridine derivatives and its salts for treating or reventin osteoporosis 등록 2008.09.05
2 Rosamine compounds for pluripotent stem cell probe 출원 2011.08.22
3 Fluorescent chemical dys for visualization of Neural Stem Cell Symmetric and Asymmetric Division 등록 2012.10.29
4 BODIPY Structure Fluorescence Probes for Diverse Biological Applications 등록 2013.02.13
5 아트라릭산을 포함하는 발모 촉진 및 탈모 방지용 조성물(Composition for promoting hair growth and preventing hair loss comprising atraric acid) 등록 2021.01.19
6 신규한 쿠마린 유도체 및 이를 포함하는 암 전이 및 침윤 억제, 또는 암 치료용 조성물 등록 2023.03.08
목록